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Chinese Journal of Dental Research
Chin J Dent Res 13 (2010), No. 2     31. Dec. 2010
Chin J Dent Res 13 (2010), No. 2  (31.12.2010)

Page 153-156, PubMed:21264367

Saponins from Plumeria acuminata Ait Induce Cell Growth Inhibition and Apoptosis of Oral Squamous Carcinoma Cells
Susanto, Hendri / Fakhrudin, Nanang / Murti, Yosi Bayu / Supriatno / Siswomiharjo, Widowati
Objective: To investigate the cytotoxic and apoptotic effects of saponins from Plumeria acuminata Ait on oral squamous carcinoma cells (OSCC).
Methods: OSCC cells seeded at 2 × 104 cells/well in a 96-well plate were treated with saponins from P. acuminata Ait and cisplatin in various concentrations for 24 h. Trypan blue dye exclusion assay and ethidium bromide/acridine orange were used to evaluate their cytotoxic and apoptotic effects on the cells, respectively.
Results: The results showed that both saponins and cisplatin had cytotoxic and apoptotic effects on OSCC cells.
Conclusion: Saponins from P. acuminata Ait may be potential anti-cancer agents for OSCC.

Keywords: apoptosis, OSCC, Plumeria acuminata Ait, saponins