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Chinese Journal of Dental Research
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Chin J Dent Res 23 (2020), No. 3     15. Sep. 2020
Chin J Dent Res 23 (2020), No. 3  (15.09.2020)

Page 191-197, doi:10.3290/j.cjdr.a45223, PubMed:32974619

Biomarkers in Metabolic Syndrome Patients with Chronic Periodontitis
Li, Peng / He, Lu / Chen, Zhi Bin / Luan, Qing Xian
Objectives: To investigate whether the levels of serum C-reactive protein (CRP), salivary interleukin (IL)-6 and IL-lβ in metabolic syndrome (MS) patients can be potential monitors for inflammation in MS patients with severe periodontitis.
Methods: A total of 114 MS patients and 49 systemically healthy subjects were enrolled. CRP in serum and IL-1β and IL-6 in non-stimulated whole saliva were collected from these patients and subjects and analysed by enzyme-linked immunosorbent assay (ELISA). Dental examinations were performed and the participants completed a questionnaire.
Results: The serum CRP level of MS patients was higher than that of systemically healthy subjects, and increased as the number of components increased (P < 0.05). No difference was observed in the salivary level of IL-6 and IL-1β between MS patients and controls or between MS patients with different components. The level of salivary IL-6 in MS patients with moderate/severe periodontitis was significantly higher than in MS patients with good periodontal health/mild periodontitis (P < 0.05). After adjustment for age, sex and smoking habits, multivariate analysis showed that the corresponding odds ratio (OR) for MS combined with moderate/severe periodontitis was 1.21 (95% confidence interval [CI] 1.04–1.39, P = 0.012) for subjects with high serum CRP and salivary IL-6 and IL-1β were not risk indicators for MS combined with moderate/severe periodontitis.
Conclusions: MS patients might be burdened by high levels of serum CRP. Serum CRP could be a potentially valuable biomarker to detect inflammation in MS patients with severe periodontal disease.

Keywords: cytokines, inflammation, metabolic syndrome, periodontitis