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Chinese Journal of Dental Research
Chin J Dent Res 22 (2019), No. 1     28. Feb. 2019
Chin J Dent Res 22 (2019), No. 1  (28.02.2019)

Page 57-64, doi:10.3290/j.cjdr.a41776, PubMed:30746534

Evaluation of Paste Containing Gentamicin, Amoxicillin and Metronidazole in Endodontic Treatment of Primary Molars in Vivo
Parakh, Keyura / Shetty, Raghavendra Manjunath
Objective: To evaluate and compare the efficacy of gentamicin, amoxicillin and metronidazole (GAM) antibiotic paste in noninstrumentation and instrumentation techniques in infected primary molars.
Methods: Sixty primary molars in children of 4 to 8 years were selected and divided into four groups: teeth without any periapical or furcation involvement undergoing pulpectomy by noninstrumentation (Group N1) and instrumentation (Group N2) technique using GAM antibiotic paste; teeth with periapical or furcation involvement undergoing pulpectomy by noninstrumentation (Group R1) and instrumentation (Group R2) technique using GAM antibiotic paste. Regular follow-up at 3, 6 and 12 months was carried out for each group and all the clinical and radiographic changes were evaluated statistically using SPSS software. The level of significance was set to P < 0.05.
Results: Overall, 73.3% of success was observed in Group N1, 71.4% in Group N2, 86.7% in both Group R1 and Group R2 (P = 0.003).
Conclusion: The GAM lesion sterilisation and tissue repair (GAM-LSTR) technique can be an alternative to conventional pulpectomy.

Keywords: antibiotic paste, primary molars, pulpectomy, gentamicin, amoxicillin, metronidazole