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Chinese Journal of Dental Research
Chin J Dent Res 19 (2016), No. 1     31. Mar. 2016
Chin J Dent Res 19 (2016), No. 1  (31.03.2016)

Page 49-54, doi:10.3290/j.cjdr.a35697, PubMed:26981607

Preliminary Evaluation of Platelet Rich Fibrin-Mediated Tissue Repair in Immature Canine Pulpless Teeth
Wang, Qi Lin / Yang, Pan Pan / Ge, Li Hong / Liu, He
Objective: To evaluate the use of platelet-rich fibrin (PRF) in the regenerative therapy of immature canine permanent teeth.
Methods: Eight immature premolars of beagle dogs were pulp extracted and cleaned with irrigation, then divided into two groups of empty root canals and those filled with a PRF clot. All of the eight premolars were sealed with mineral trioxide aggregate and glass ionomer cement. Two premolars were left naturally grown as a positive control. The root development was assessed radiographically and histologically after 12 weeks.
Results: The radiological findings showed greater increases in the thickness of lateral dentinal wall in the PRF group than in the vacant group. Histologically, dental-associated mineral tissue, connective tissue, and bone-like mineral tissue grew into the root canals independent of PRF clot use. The PRF was able to increase the thickness of dental-associated mineral tissue. However, the vital tissue differed from the pulp dentin complex.
Conclusion: Our study demonstrated the feasibility of using PRF-mediated regenerative therapy in pulpless immature teeth for improving tissue repair.

Keywords: histological results, immature canine teeth, platelet-rich fibrin, pulp repair