We are using cookies to implement functions like login, shopping cart or language selection for this website and to create anonymized statistical reports of the usage. You will find more information in our privacy policy. By continuing to use our website, you agree to this. Yes, I agree
Chinese Journal of Dental Research
Chin J Dent Res 15 (2012), No. 1     13. July 2012
Chin J Dent Res 15 (2012), No. 1  (13.07.2012)

Page 25-29, PubMed:22866279


Lipoprotein-associated Phospholipase A2 and Serum Lipid Levels in Supjects with Chronic Periodontitis and Hyperlipidemia
Zhou, Shuang Ying / Xiao, Wen Mei / Ouyang, Xiang Ying
Objective: To evaluate the relationships between clinical periodontal parameters and levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and lipid profile markers in subjects with or without hyperlipidaemia.
Methods: Forty chronic periodontitis (CP) subjects with hyperlipidaemia (CP/HPL group), 40 systemically healthy CP subjects (CP group) and 20 systemically and periodontally healthy subjects (control group) were enrolled. The clinical periodontal parameters, the serum concentrations of Lp-PLA2, lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and white blood cell (WBC) counts were determined and compared between different groups. Linear regression analysis was performed to identify the contributing factors of Lp-PLA2.
Results: Serum Lp-PLA2 level in the CP/HPL group and the CP group was significantly higher than in the healthy group. TC and TG levels in the CP/HPL group were higher than in the CP and control groups. No difference was observed for levels HDL-c and LDL-c and WBC counts among the groups. Linear regression analysis showed that the serum level of Lp-PLA2 was positively associated with bleeding on probing and WBC counts.
Conclusion: Elevated level of Lp-PLA2 is associated with periodontal inflammation, indicating that periodontal treatment could reduce the risk of cardiovascular disease in CP subjects with hyperlipidaemia.

Keywords: periodontitis, hyperlipidaemia, lipoprotein-associated phospholipase A2